SKN-1/Nrf, A New Unfolded Protein Response Factor?
نویسندگان
چکیده
منابع مشابه
SKN-1/Nrf, A New Unfolded Protein Response Factor?
Cell function requires simultaneous regulation of numerous processes, often under variable conditions. Several inducible pathways have been defined as being responsible for maintaining homeostasis under the threat of a particular stress such as heat, oxidizing conditions, exposure to pathogens, or loss of proteostasis. The challenge now is to understand how and why these pathways interact in ba...
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Originating from cancer research in mammalian cultured cells, the entirely new field of the unfolded protein response (UPR) was born in 1988. The UPR is a transcriptional induction program coupled with intracellular signaling from the endoplasmic reticulum (ER) to the nucleus to maintain the homeostasis of the ER, an organelle which controls the quality of proteins destined for the secretory pa...
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Where does the UPR function? Between the endoplasmic reticulum (ER) and the nucleus of eukaryotic cells. All secreted proteins and proteins that reside in secretory compartments translocate as nascent peptide chains into the ER, where they may undergo folding, modification and assembly before assuming their functional conformations. The ER maintains a specialized oxidizing environment to aid ch...
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yeasts have rewired many regulatory networks, such that processes as diverse as ribosomal protein gene regulation, galactose metabolism and mating-type switching, which appear to be very similar at the physiological level, are regulated by different transcription factors that bind to different regulatory sequences. Despite its evolutionary distance to S. cerevisiae being relatively short, C alb...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2013
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1003827